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Using hybrid models to predict blood pressure reactivity to unsupported back based on anthropometric

Gurmanik KAUR,Ajat Shatru ARORA,Vijender Kumar JAIN

《信息与电子工程前沿（英文）》 2015年 第16卷 第6期   页码 474-485 doi: 10.1631/FITEE.1400295

摘要： Accurate blood pressure (BP) measurement is essential in epidemiological studies, screening programmes, and research studies as well as in clinical practice for the early detection and prevention of high BP-related risks such as coronary heart disease, stroke, and kidney failure. Posture of the participant plays a vital role in accurate measurement of BP. Guidelines on measurement of BP contain recommendations on the position of the back of the participants by advising that they should sit with supported back to avoid spuriously high readings. In this work, principal component analysis (PCA) is fused with forward stepwise regression (SWR), artificial neural network (ANN), adaptive neuro-fuzzy inference system (ANFIS), and the least squares support vector machine (LS-SVM) model for the prediction of BP reactivity to an unsupported back in normotensive and hypertensive participants. PCA is used to remove multi-collinearity among anthropometric predictor variables and to select a subset of components, termed ‘principal components’ (PCs), from the original dataset. The selected PCs are fed into the proposed models for modeling and testing. The evaluation of the performance of the constructed models, using appropriate statistical indices, shows clearly that a PCA-based LS-SVM (PCA-LS-SVM) model is a promising approach for the prediction of BP reactivity in comparison to others. This assessment demonstrates the importance and advantages posed by hybrid models for the prediction of variables in biomedical research studies.

关键词： Blood pressure (BP)     Principal component analysis (PCA)     Forward stepwise regression     Artificial neural network (ANN)     Adaptive neuro-fuzzy inference system (ANFIS)     Least squares support vector machine (LS-SVM)    

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Non-invasive continuous blood pressure monitoring: a review of current applications

null

《医学前沿（英文）》 2013年 第7卷 第1期   页码 91-101 doi: 10.1007/s11684-013-0239-5

摘要：

Blood pressure monitoring has come a long way from the initial observations made by Reverend Hales in the 18th century. There are none that deny the importance of monitoring perioperative blood pressure; however, the limited ability of the current prevalent technology (oscillometric blood pressure monitoring) to offer continuous blood pressure measurements leaves room for improvement. Invasive monitoring is able to detect beat-to-beat blood pressure measurement, but the risks inherent to the procedure make it unsuitable for routine use except when this risk is outweighed by the benefits. This review focuses on the discoveries which have led up to the current blood pressure monitoring technologies, and especially the creation of those offering non-invasive but continuous blood pressure monitoring capabilities, including their methods of measurement and limitations.

关键词： non-invasive blood pressure monitoring     continuous blood pressure monitoring     invasive blood pressure monitoring     Riva-Rocci technique     oscillometric     Pe?áz technique     arterial tonometry     pulse transit time    

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Relationship of endothelial nitric oxide synthase gene polymorphism with blood pressure, lipid profileand blood glucose level

TANG Zhongzhi, LI Junyao, YANG Jianhong

《医学前沿（英文）》 2008年 第2卷 第2期   页码 178-181 doi: 10.1007/s11684-008-0033-y

摘要： To study the relationship of the polymorphism of endothelial nitric oxide synthase (eNOS) gene and blood pressure, lipid profiles and blood glucose level. By using PCR-RFLP, the eNOS Glu298Asp gene polymorphism was detected in 184 patients with essential hypertension and 196 matched healthy individuals with normal blood pressure. Taking into account eNOS Glu298Asp polymorphisms, the relationship of blood pressure with triglycerides (TG), total cholesterol (TC), high density lipoprotein (HDL), low density lipoprotein (LDL) and blood glucose level was analyzed. The distribution of eNOS Glu298Asp polymorphism had no significant difference between different blood pressure groups and gender groups, but there was a significant difference between different age groups, diastolic blood pressure groups or BMI groups ( < 0.05). Asp/Asp genotype significantly increased the risk of hypertension in individuals with serum TC above 5.4 mmol/L ( = 0.03, = 2.65). eNOS Glu298Asp polymorphism and serum lipid could synergistically modulate the blood pressure. eNOS Asp/Asp genotype could significantly increase the risk of hypertension in individuals with serum TC over 5.4 mmol/L. eNOS Glu298Asp in combination with serum TC could be used to predict the risk of hypertension.
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Effects of RNA interference targeting angiotensin 1a receptor on blood pressure and cardiac hypertrophy

ZHANG Jingqun, SUN Honglei, MA Yexin, WANG Daowen

《医学前沿（英文）》 2008年 第2卷 第1期   页码 19-24 doi: 10.1007/s11684-008-0005-2

摘要： The aim of this study is to investigate the effects of RNA interference (RNAi) targeting angiotensin 1a receptor (AT1a) on blood pressure and cardiac hypertrophy of rats with renovascular hypertension. Two RNAi plasmids, pAT1a-shRNA1 and pAT1a-shRNA2 each carrying a U6 promoter and an AT1a-specific shRNA-coding template sequence corresponding to the sites 928–946, 978–996 of the mRNA transcript, and a control plasmid pCon carrying a nonspecific shRNA-coding sequence were constructed. Thirty Sprague – Dawley rats with renovascular hypertension (2-kidney 1-clip) were randomly divided into 5 equal groups: Control group (without any intervention), pAT1a-shRNA1, pAT1a-shRNA2, pCon groups (with injection of the corresponding plasmid 4 mg/kg respectively into the tail vein), and valsartan group (30 mg/kg·d by gavage). Three weeks after drug administration, pAT1a-shRNA1, pAT1a-shRNA2 and valsartan respectively resulted in decrease of the tail blood pressure by (15.1 ± 5.4), (16.4 ± 8.4) and (30.6 ± 18.2) mmHg. However, the tail blood pressure increased further by about 25 mmHg in both of pCon and control groups. The carotid artery pressures of pAT1a-shRNA1, pAT1a-shRNA2 and valsartan groups were all significantly lower than those of the control and pCon groups. The ratio of left ventricle weight to body weight (LV/BW) of the rats in pAT1a-shRNA1, pAT1a-shRNA2, and valsartan groups decreased significantly than in the control group ( < 0.01), similar to those of the normal SD rats( > 0.05). Histopathological examination showed that the myocardiocytes were significantly hypertrophic and the basal membrane of the aorta was significantly thickened in the control group and such changes were alleviated in the pAT1a-shRNA1, pAT1a-shRNA2 and valsartan groups. Compared with the control group, pAT1a-shRNA1 and pAT1a-shRNA2 groups had lowered expression of AT1 receptor (in the myocardium and the thoracic aorta (all < 0.01); however, there were no significant differences in expression levels of AT1 receptor in valsartan and the control groups ( > 0.05). We conclude that RNAi targeting AT1a receptor inhibits the development of renovascular hypertension and the accompanying cardiac hypertrophy. RNAi technology may become a new strategy of gene therapy for hypertension.

关键词： therapy     Sprague     administration     cardiac hypertrophy     valsartan    

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基于GA－BP网络的人工湿地污水净化效果研究

黄娟,王世和,雒维国,钱卫一,鄢璐

《中国工程科学》 2007年 第9卷 第2期   页码 79-83

摘要： 基于大量可靠的试验数据，首次采用遗传神经网络方法模拟湿地除污系统， 详细论述了网络拓扑结构优化和训练数据预处理等关键问题，建立了可靠的GA－BP模型，并采用该模型仿真湿 地系统正交试验，依据正交试验结果对影响因素进行分级

关键词： 人工湿地     污水净化     GA-BP网络     正交试验    

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Improved control of hypertension following laparoscopic fundoplication for gastroesophageal reflux disease

null

《医学前沿（英文）》 2017年 第11卷 第1期   页码 68-73 doi: 10.1007/s11684-016-0490-7

摘要：

This study aims to determine whether successful laparoscopic fundoplication for gastroesophageal reflux disease (GERD) can improve the control of hypertension. We conducted an observational study of GERD patients with hypertension. The esophageal and gastroesophageal symptoms of these patients were successfully treated with laparoscopic fundoplication, as measured by the reduced GERD symptoms and proton pump inhibitor consumption. A hypertension control scale was used to classify the use of antihypertensive medications and the quality of blood pressure control before and after anti-reflux surgery. Wilcoxon signed-ranks test was used for the statistical analyses. Seventy GERD patients were included in the analysis and followed up for a mean period of 3.5±1.4 years. Prior to surgery, all participating patients were taking at least one class of antihypertensive medication, and 56 patients (80%) had intermittently high blood pressure. After surgery, the mean number of antihypertensive medication classes per patient was significantly reduced from 1.61±0.77 pre-procedure to 1.27±0.88 post-procedure (P?<?0.001). The blood pressure of 48 of the 56 cases (86%) with preoperative intermittent high blood pressure returned to normal post procedure. A total of 50 patients (71%) recorded improvements on the hypertension control scale, with the overall mean score decreasing from 3.1±1.0 pre-procedure to 1.4±1.0 post-procedure (P?<?0.001). Therefore, successful laparoscopic fundoplication may result in better blood pressure control in some hypertensive GERD patients. This result suggests a possible connection between gastroesophageal reflux and hypertension.

关键词： gastroesophageal reflux disease     hypertension     blood pressure     laparoscopic fundoplication    

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基于正交实验的BP神经网络预测研究

蔡安辉,刘永刚,孙国雄

《中国工程科学》 2003年 第5卷 第7期   页码 67-71

摘要：

用不同的L9（34）正交实验方案结果作为训练学习样本集，对BP神经网络预测应用过程的策略进行了探讨，结果表明：完备的正交实验样本集是基本训练学习单元，在完备的正交实验样本集上添加或减少样本数量同一实验的条件下，完备的信息量大的正交实验样本集，能以很高的精度预测完备的信息量小的正交实验样本集；提出了一条新的实验设计思路——通过实验得出一个完备的正交实验样本集，通过计算机用BP

关键词： BP神经网络     正交实验     策略     实验设计思路     样本集    

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一种改进BP算法在机械手逆运动学中的应用

吴爱国,郝润生

《中国工程科学》 2005年 第7卷 第7期   页码 34-38

摘要：

通过对传统BP算法的分析，提出了一种改进激励函数的学习方法，并且在神经网络的每一层采用不同的学习速率，以提高训练速度；采用所提出的改进BP算法，训练多层前向神经网络，建立机械手逆运动学模型，仿真结果表明了该算法的有效性；与传统BP算法相比，大大提高了机械手逆运动学的精度。

关键词： 神经网络     BP算法     激励函数     机械手     逆运动学    

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基于BP神经网络的工程图形数据远程安全快速传输法

秦威,秦书玉

《中国工程科学》 2007年 第9卷 第1期   页码 49-52

摘要： 根据图形的几何元素相关性的特征，建立参数结构，采用人工神经网络BP算法同时进行数据编码 压缩和数据加密，实现复杂工程图形数据的远程高效安全传输。实例表明，此方法可用于实际工程。

关键词： 神经网络     BP算法     相关性     加密     快速传输     图形数据    

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Optimization of turbine cold-end system based on BP neural network and genetic algorithm

Chang CHEN,Danmei XIE,Yangheng XIONG,Hengliang ZHANG

《能源前沿（英文）》 2014年 第8卷 第4期   页码 459-463 doi: 10.1007/s11708-014-0335-5

摘要： The operation condition of the cold-end system of a steam turbine has a direct impact on the economy and security of the unit as it is an indispensible auxiliary system of the thermal power unit. Many factors influence the cold-end operation of a steam turbine; therefore, the operation mode needs to be optimized. The optimization analysis of a 1000 MW ultra-supercritical (USC) unit, the turbine cold-end system, was performed utilizing the back propagation (BP) neural network method with genetic algorithm (GA) optimization analysis. The optimized condenser pressure under different conditions was obtained, and it turned out that the optimized parameters were of significance to the performance and economic operation of the system.

关键词： optimization     turbine     cold-end system     BP neural network     genetic algorithm    

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基于BP-AGA的非线性组合预测方法研究

王硕,张有富,金菊良

《中国工程科学》 2005年 第7卷 第4期   页码 83-87

摘要：

运用神经网络和加速遗传算法建立非线性组合预测模型，在BP算法训练网络出现收敛速度缓慢时启用加速遗传算法（AGA）来优化网络参数，把AGA的优化结果作为BP算法的初始值，再用BP算法训练网络，如此交替运行BP算法和AGA以加快网络的收敛速度，同时改善局部最小问题。

关键词： 神经网络     加速遗传算法     非线性组合预测     预测精度    

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Genetic variants in the ADD1 and GNB3 genes and blood pressure response to potassium supplementation

Dai-Hai YU PhD, Jian-Feng HUANG MD, Ji-Chun CHEN MS, Jie CAO MS, Shu-Feng CHEN PhD, Dong-Feng GU MD, PhD, for the GenSalt Collaborative Research Group, De-Pei LIU PhD, Lai-Yuan WANG PhD, Jing CHEN MD, MSc, Jiang HE MD, PhD, Cashell E. JAQUISH PhD, Dabeeru C. RAO PhD, Charles GU PhD, James E. HIXSON PhD, Chung-Shiuan CHEN MS8, Paul K. WHELTON MD, MSc9,

《医学前沿（英文）》 2010年 第4卷 第1期   页码 59-66 doi: 10.1007/s11684-010-0015-8

摘要： Dietary potassium-supplementation has been associated with a decreased risk of hypertension and other cardiovascular outcomes. However, blood pressure (BP) responses to potassium supplementation vary among individuals. This study was designed to examine the association between 12 single nucleotide polymorphisms (SNPs) in the adducin 1 alpha (ADD1) and guanine nucleotide binding protein (G protein) beta polypeptide 3 (GNB3) genes and systolic BP (SBP), diastolic BP (DBP), and mean arterial pressure (MAP) responses to potassium-supplementation. We conducted a 7-day high-sodium intervention (307.8 mmol sodium/day) followed by a 7-day high-sodium with potassium-supplementation (60 mmol potassium/day) among 1906 Han Chinese participants from rural north China. BP measurements were obtained at the end of each intervention period using a random-zero sphygmomanometer. We identified significant associations between ADD1 variant rs17833172 and SBP, DBP, and MAP responses to potassium-supplementation (all <0.0001) that remained significant after adjustment for multiple comparisons. In participants that were heterozygous or homozygous for the G allele of this marker, SBP, DBP, and MAP response to potassium-supplementation were −3.52 (−3.82, −3.21), −1.41 (−1.66, −1.15) and −2.12 (−2.37, −1.87), respectively, as compared to the corresponding responses of 1.99 (0.25, 3.73), −0.65 (−0.10, −0.21), and −0.23 (−0.37, 0.83), respectively, for those who were homozygous for A allele. In addition, participants with at least one copy of the G allele of rs12503220 of the ADD1 gene had significantly increased DBP and MAP response to potassium-supplementation ( = 0.0041 and 0.01, respectively), which was also significant after correction for multiple testing. DBP and MAP responses to potassium-supplementation were −1.36 (−1.63, −1.10) and −2.07 (−2.32, −1.82) for those with at least G allele compared to corresponding responses of 0.86 (−0.68, 2.40) and −0.45 (−1.74, 0.84) for those who were homozygous for A allele. In summary, our study identified novel associations between genetic variants of the ADD1 gene and BP response to potassium-supplementation, which could have important clinical and public health implications. Future studies aimed at replicating these novel findings are warranted.

关键词： blood pressure     genetics     polymorphism     die-tary potassium     potassium sensitivity     adducin 1 alpha (ADD1)     guanine nucleotide binding protein beta polypeptide 3 (GNB3)    

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White blood cell count and the incidence of hyperuricemia: insights from a community-based study

Jian Liu, Pingyan Shen, Xiaobo Ma, Xialian Yu, Liyan Ni, Xu Hao, Weiming Wang, Nan Chen

《医学前沿（英文）》 2019年 第13卷 第6期   页码 741-746 doi: 10.1007/s11684-017-0579-7

摘要： Hyperuricemia (HUA) is a risk factor for chronic kidney disease (CKD). The relationship between HUA and white blood cell (WBC) count remains unknown. A sampling survey for CKD was conducted in Sanlin community in 2012 and 2014. CKD was defined as proteinuria in at least the microalbuminuric stage or an estimated GFR of 60 mL/(min·1.73 m ). HUA was defined as serum uric acid>420 µmol/L in men and>360 µmol/L in women. This study included 1024 participants. The prevalence of HUA was 17.77%. Patients with HUA were more likely to have higher levels of WBC count, which was positively associated with HUA prevalence. This association was also observed in participants without CKD, diabetes mellitus, hyperlipidemia, or obesity. Multivariate logistic regression analysis showed that WBC count was independently associated with the risk for HUA in male and female participants. Compared with participants without HUA, inflammatory factors such as high-sensitivity C-reactive protein, tumor necrosis factor-α and interleukin 6 increased in participants with HUA. Hence, WBC count is positively associated with HUA, and this association is independent of conventional risk factors for CKD.

关键词： white blood cell count     hyperuricemia     chronic kidney disease     inflammation    

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一种BP神经网络的改进方法及其应用

李宏刚,吕辉,李刚

《中国工程科学》 2005年 第7卷 第5期   页码 63-65

摘要：

针对BP神经网络中学习因子取值小、收敛性好但训练时间长，学习因子取值大、权值变化剧烈但可能导致振荡的情况，提出了一种修正学习因子的方法，即给学习因子前加一比例因子，在网络权值调整过程中自动调整学习因子的大小

关键词： 神经网络     改进算法     仿真    

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gelatin-heparin nanofibrous scaffolds formed by a bi-layer electrospinning technique as potential artificial blood

Heyun WANG, Yakai FENG, Marc BEHL, Andreas LENDLEIN, Haiyang ZHAO, Ruofang XIAO, Jian LU, Li ZHANG, Jintang GUO

《化学科学与工程前沿（英文）》 2011年 第5卷 第3期   页码 392-400 doi: 10.1007/s11705-011-1202-0

摘要： In this paper, a scaffold, which mimics the morphology and mechanical properties of a native blood vessel is reported. The scaffold was prepared by sequential bi-layer electrospinning on a rotating mandrel-type collector. The tubular scaffolds (inner diameter 4 mm, length 3 cm) are composed of a polyurethane (PU) fibrous outer-layer and a gelatin-heparin fibrous inner-layer. They were fabricated by electrospinning technology, which enables control of the composition, structure, and mechanical properties of the scaffolds. The microstructure, fiber morphology and mechanical properties of the scaffolds were examined by means of scanning electron microscopy (SEM) and tensile tests. The PU/gelatin-heparin tubular scaffolds have a porous structure. The scaffolds achieved a breaking strength (3.7±0.13 MPa) and an elongation at break (110±8%) that are appropriate for artificial blood vessels. When the scaffolds were immersed in water for 1 h, the breaking strength decreased slightly to 2.2±0.3 MPa, but the elongation at break increased to 145±21%. In platelet adhesion tests the gelatin-heparin fibrous scaffolds showed a significant suppression of platelet adhesion. Heparin was released from the scaffolds at a fairly uniform rate during the period of 2 day to 9 day. The scaffolds are expected to mimic the complex matrix structure of native arteries, and to have good biocompatibility as an artificial blood vessel owing to the heparin release.

关键词： electrospinning     artificial blood vessels     scaffold     polyurethane     gelatin     nanofiber     hemocompatibility    

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标题 作者 时间 类型 操作

Using hybrid models to predict blood pressure reactivity to unsupported back based on anthropometric

Gurmanik KAUR,Ajat Shatru ARORA,Vijender Kumar JAIN

期刊论文

Non-invasive continuous blood pressure monitoring: a review of current applications

null

期刊论文

Relationship of endothelial nitric oxide synthase gene polymorphism with blood pressure, lipid profileand blood glucose level

TANG Zhongzhi, LI Junyao, YANG Jianhong

期刊论文

Effects of RNA interference targeting angiotensin 1a receptor on blood pressure and cardiac hypertrophy

ZHANG Jingqun, SUN Honglei, MA Yexin, WANG Daowen

期刊论文

基于GA－BP网络的人工湿地污水净化效果研究

黄娟,王世和,雒维国,钱卫一,鄢璐

期刊论文

Improved control of hypertension following laparoscopic fundoplication for gastroesophageal reflux disease

null

期刊论文

基于正交实验的BP神经网络预测研究

蔡安辉,刘永刚,孙国雄

期刊论文

一种改进BP算法在机械手逆运动学中的应用

吴爱国,郝润生

期刊论文

基于BP神经网络的工程图形数据远程安全快速传输法

秦威,秦书玉

期刊论文

Optimization of turbine cold-end system based on BP neural network and genetic algorithm

Chang CHEN,Danmei XIE,Yangheng XIONG,Hengliang ZHANG

期刊论文

基于BP-AGA的非线性组合预测方法研究

王硕,张有富,金菊良

期刊论文

Genetic variants in the ADD1 and GNB3 genes and blood pressure response to potassium supplementation

Dai-Hai YU PhD, Jian-Feng HUANG MD, Ji-Chun CHEN MS, Jie CAO MS, Shu-Feng CHEN PhD, Dong-Feng GU MD, PhD, for the GenSalt Collaborative Research Group, De-Pei LIU PhD, Lai-Yuan WANG PhD, Jing CHEN MD, MSc, Jiang HE MD, PhD, Cashell E. JAQUISH PhD, Dabeeru C. RAO PhD, Charles GU PhD, James E. HIXSON PhD, Chung-Shiuan CHEN MS8, Paul K. WHELTON MD, MSc9,

期刊论文

White blood cell count and the incidence of hyperuricemia: insights from a community-based study

Jian Liu, Pingyan Shen, Xiaobo Ma, Xialian Yu, Liyan Ni, Xu Hao, Weiming Wang, Nan Chen

期刊论文

一种BP神经网络的改进方法及其应用

李宏刚,吕辉,李刚

期刊论文

gelatin-heparin nanofibrous scaffolds formed by a bi-layer electrospinning technique as potential artificial blood

Heyun WANG, Yakai FENG, Marc BEHL, Andreas LENDLEIN, Haiyang ZHAO, Ruofang XIAO, Jian LU, Li ZHANG, Jintang GUO

期刊论文